This workshop focuses on the challenges of a service mesh. To demonstrate this, multiple MicroProfile and SpringBoot based microservices will be combined together with Istio to form a service mesh. Based on concrete code samples we will learn how the necessary Istio rules work together with these services. We will explicitly show different real world requirements such as configuration, tracing, resilience and testing and combine them with best practices. In addition, the workshop shows what other features Istio offers to avoid wrecking in everyday use of distributed applications. All participants will receive the slides and code samples, together with the relevant Kubernetes/Istio scripts. A special handout will be an Istio cheat sheet and a collection of Istio best practices.